EPOCAL's Medical Lab Diagnostics on an active Microfluidic Smart Card

Epocal, based in Ottawa Canada, a microfluidics health care diagnostics firm founded by Dr. Imants Lauks, is building a novel compact microfluidics blood diagnostics analyzer on a card, for wide deployment in health care facilities.

Dr. Lauks previously was the founder of i-Stat, later acquired by Abbott, whose biochip based products provide hand held solutions for a number of critical care assays, including: Blood Gases, Electrolytes, Chemistries, Coagulation, Hematology, and Cardiac Markers (cTnI).

Epocal is noteworthy for its vertically integrating microfluidics process / manufacturing capability, with medical chemistry applications expertise.

Where the i-Stat's devices seemed to be mostly passive dedicated substrate sample chips, the Epocal solutions will be lab on a card ( smart card format with integrated active microfluidics, sensors and reagents ) deployed to be measured and logged on small Epocal card readers in the hospital floor setting.

No muss nor fuss - all the wetted parts - channels and sensors and pumps, are on the disposable cost effective smart cards.

Noteworthy is the development at Epocal of smart microfluidic card manufacturing on flex - ie roll to roll substrates. And leveraging the considerable infrastructure / industrial tooling of smart card manufacturing.

This - use of mostly industry standardized smart card manufacturing tooling - is rare for recent attempts to commercialize biotech microfludics diagnostics, especially noteworthy for being readily available off the shelf from numerous vendors.

Epocals Biosensors-on-Flex™ technology processes kapton flex circuits into biosensor arrays in a single continuous roll to roll manufacturing process.

Epocal uses Roll to Roll processing - from raw material manufacturing start, all the way through to finished diagnostic card ready for shipment and use, with rapid throughput in manufacturing.

Roll to Roll Flex circuits are processed using machinery modifed from standard smart card manufacturing, on standard tape-on-reel tooling

Epocal's smart flex substrate cards integrate all active and passive microfluidics to eliminate the need for external pumps, detectors, reagent cartridges etc.

This is a practical manufacturable commercial implementation of micro TAS - Total Analysis System, with a large targetted focused market - hospital blood chemistry tests - test results faster and cheaper than ever before.

The flex kapton based smart card module, forming microfluidics with through vias and back-side metal, is the platform for a generalized biosensor micro Total Analysis system. Each card film via through hole pocket, when loaded with membrane or chemical reagent, implements a microscale bioreactor with integral electrochemical detector.

Membranes and reagents are loaded by roll to roll process integrated micro-dispensing onto the 35mm tape carrier, resulting in the lowest cost solution of any integrated biosensor technology.

Epocal has developed membranes and reagents for application in blood tests that include electrolytes, dissolved gases, hematocrit, and metabolites. Epocal's initial product will be capable of 8 tests, later expandable to12 tests per card.

My take is this firm will be another blockbuster from Dr. Lauks - comparable but likely better than i-Stat became.

Epocal Inc.
2319 St. Laurent Boulevard, Suite 500
Ottawa Ontario K1G 4J8 Canada
Phone: 613-738-6192 Fax: 613-738-6195

recent news from Epocal

Epocal Inc. Completes $31 Million Series C Financing 4/11/2007

Epocal Inc. Receives FDA Approval To Market The EPOCTM Blood Analysis System 0/12/2006

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MW - postscript Sept 2007 -

Below are some pictures explaining the function of the Epocal microfluidics smart cards, unique for being early in clinical diagnostics deployment, with the high functional complexity on the plastic card, supported by the readers and data management system. Click on them to see higher resolution images.












Here are the published patent and patent applications at USPTO of Epocal at the moment.

US20070170062	INTEGRATED ELECTROKINETIC DEVICES AND METHODS OF MANUFACTURE Devices with electrokinetic elements are disclosed as well as their method of microfabrication for use in micro-scale analysis, mixture separation and reaction. The devices consist of solid hydrophilic-matrix films that have been microfa...
7214300	Integrated electrokinetic devices and methods of manufacture Devices with electrokinetic elements are disclosed as well as their method of microfabrication for use in micro-scale analysis, mixture separation and reaction. The devices consist of solid hydrophilic-matrix films that have been microfa...
7201833	Integrated solid-phase hydrophilic matrix circuits and micro-arrays The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integr...
7094330	Heterogeneous membrane electrodes The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and economical construction, ...
US20050150761	Electrode module A chip-carrier module known from smart card technology is adapted as an electrode array for use in disposable sensing or separation devices containing electrodes. The electrodes are manufactured directly onto chip-carrier module. The pre...
6896778	Electrode module Planar devices incorporating electrodes for performing chemical analyses are disclosed. The devices include an electrode module in a fluidic housing. The electrode module includes a carrier module and at least one electrode thereon. More...
6845327	Point-of-care in-vitro blood analysis system Devices for cost-effectively performing in-vitro diagnostic chemical analyses at multiple distributed locations within a medical institution are disclosed. One object of this invention is to provide a network of distributed sensory devic...

And here are issued patents at the Canadian Patent Office (CIPO)

CIPO - Patent - 2449388 INTEGRATED ELECTROKINETIC DEVICES AND METHODS OF MANUFACTURE



CIPO - Patent - 2547701 INTEGRATED SOLID-PHASE HYDROPHILIC MATRIX CIRCUITS AND MICRO-ARRAYS

CIPO - Patent - 2449511 POINT-OF-CARE IN-VITRO BLOOD ANALYSIS SYSTEM




CIPO - Patent - 2449172 PLANAR ELECTRODE MODULE FOR USE IN A DIAGNOSTIC DEVICE

CIPO - Patent - 2547698 POTENTIOMETRIC REFERENCE ELECTRODE WITH HETEROGENEOUS MEMBRANE

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Watch for Epocal.....mw

wendman nanotechnology nano nanotech microfluidics Lab+On+A+Chip microTAS DNA+Sequencing Cornell Craighead Watt+Webb KPCB EPOCAL Dalsa MedLab MEMS Jurvetson Pacific+Biosciences Bioengineering Andrew+Berlin